Research

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“I think if one is true to oneself and give yourself space and time to just ask the questions as to what else is needed? And how do we do this? What is it that we can do? And you find the solutions and you go for it. And you mustn’t give up faith and trust in that intervention, especially when people are benefitting from it. It’s one of these universal laws that if we look after other people well and as best as we can with integrity and honesty, you are on the right track. The possibilities that open when you are doing this, it’s like amazing. So you always know that, one thing I’ve learnt is that there will always be space to be innovative, when it comes to helping other people and that in itself is immensely rewarding.”

– Dr Ashraf Grimwood, Founder and CEO, Kheth’Impilo



1. Victoria Iyun, Karl Technau, Brian Eley, Helena Rabie, Andrew Boulle, Geoffrey Fatti, Matthias Egger, Frank Tanser, Robin Wood, Lee Fairlie, Mark F. Cotton, Mary-Ann Davies. Earlier antiretroviral therapy initiation and decreasing mortality among HIV-infected infants initiating antiretroviral therapy within 3 months of age in South Africa, 2006-2017. Pediatric Infectious Diseases Journal. 2019 epub ahead of print

2. Geoffrey Fatti, Najma Shaikh, Peter Bock, Jean Nachega, Ashraf Grimwood. South African National Adherence Guidelines: Need for Revision? Tropical Medicine and International Health. 2019, 24(10): 1260–1262.

3. Peter Bock, Graeme Hoddinott, Leonard Maschilla, Rory Holtman, Nelis Grobbelaar, Dillon Wademan, Rory Dunbar, Geoffrey Fatti, James Kruger, Nathan Ford, Colette Gunst, Sue-Ann Meehan. Retention in care and factors critical for effectively implementing antiretroviral adherence clubs in a rural district in South Africa. Journal of the International AIDS Society. 2019, 22:e25396

4. Geoffrey Fatti; Ashraf Grimwood; Jean B. Nachega; Jenna Nelson; Kelsea LaSorda; Gert van Zyl; Nelis Grobbelaar; Helen Ayles; Richard Hayes; Nulda Beyers; Sarah Fidler; Peter Bock on behalf of the HPTN 071 (PopART) study team. Better Virological Outcomes amongst People Living with HIV Initiating Early Antiretroviral Treatment (CD4 cell counts ≥ 500 cells/μL) in the HPTN 071 (PopART) Trial in South Africa. Clinical Infectious Diseases. 2019 Mar 16.

5. Peter Bock, Kerry Nel, Geoffrey Fatti, Rosa Sloot, Nathan Ford, Karen Jennings, Jacqueline Voget, Colette Gunst, Nelis Grobbelaar, Francoise Louis, Sian Floyd, Richard Hayes, Helen Ayles, Nulda Beyers & Sarah Fidler on behalf of the HPTN 071 (PopART) team. Renal dysfunction by baseline CD4 cell count in a cohort of adults starting antiretroviral treatment regardless of CD4 count in the HPTN 071 (PopART) study in South Africa. HIV Medicine. 2019. 20: 392–403. epub Apr 8.

6. The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration. Incidence of switching to second-line antiretroviral therapy and associated factors in children with HIV: an international cohort collaboration. Lancet HIV. 2019; 6: e105–15 (Feb 2019).

7. David C. Boettiger, Matthew G. Law, Annette H. Sohn, Mary-Ann Davies, Kara Wools-Kaloustian, Valeriane Leroy, Marcel Yotebieng, Geoffrey Fatti, Rachel Vreeman, Andrew Edmonds, James Batte, Adebola Adedimeji and Azar Kariminia. Temporal trends in cotrimoxazole use among children on antiretroviral therapy and the impact of cotrimoxazole on rates of mortality in children without severe immune deficiency. Journal of the Pediatric Infectious Diseases Society. 2019; 8(5): 450-460 

1. Priscilla R. Tsondai, Kate Braithwaite, Geoffrey Fatti, Carolyn Bolton Moore, Cleophas Chimbetete, Helena Rabie, Sam Phiri, Shobna Sawry, Brian Eley, Janneke H van Dijk, Jonathan Euvrard, Frank Tanser, Katayoun Taghavi, Annette H. Sohn, Mary-Ann Davies. Describing the characteristics and long-term outcomes of adolescents living with perinatally acquired HIV in the IeDEA-Southern Africa Collaboration: 2004-2017. 10th IAS Conference on HIV Science, Mexico City, Mexico, 21 to 24 July 2019.

2. Priscilla R. Tsondai, Kate Braithwaite, Geoffrey Fatti, Carolyn Bolton Moore, Cleophas Chimbetete, Helena Rabie, Sam Phiri, Shobna Sawry, Brian Eley, Janneke H van Dijk, Jonathan Euvrard, Frank Tanser, Katayoun Taghavi, Annette H. Sohn, Mary-Ann Davies. Describing the characteristics and long-term outcomes of adolescents living with perinatally acquired HIV in the IeDEA-Southern Africa Collaboration: 2004-2017. 11th International Workshop on HIV & Pediatrics, Mexico City, Mexico, 19 to 20 July 2019. 

3. Reneé de Waal, Helena Rabie, Karl Technau, Brian Eley, Nosisa Sipambo, Mark Cotton, Andrew Boulle, Robin Wood, Frank Tanser, Geoffrey Fatti, Matthias Egger, Mary-Ann Davies. Abacavir safety and efficacy in young infants in South African observational cohorts. International Epidemiological Databases to Evaluate AIDS All-Africa Meeting; Johannesburg, South Africa, 30-31 October 2019.

4. Jaqualine Chaurura, Ashraf Grimwood, Eula Mothibi, Delphin Kabamba, Lizette Monteith, Mgcini Sibanda, Geoffrey Fatti, Phumuzile Hlongwane. Improving ART patients health outcomes through Community ART Refill Groups and Postes de Distribution Communautaire implementation: Lessons Learnt from Zimbabwe and Democratic Republic of Congo. 9th South African AIDS Conference, Durban, South Africa, 11–14 June, 2019. 

5. Priscilla Tsondai, Kate Braithwaite, Geoffrey Fatti, Carolyn Bolton Moore, Cleophas Chimbetete, Helena Rabie, Sam Phiri, Shobna Sawry, Brian Eley, Janneke H van Dijk, Jonathan Euvrard, Frank Tanser, Katayoun Taghavi, Annette H. Sohn, Mary-Ann Davies.. Describing the characteristics and long-term outcomes of adolescents living with perinatally acquired HIV in the IeDEA-Southern Africa Collaboration: 2004-2017. International Workshop on HIV and Hepatitis Observational Databases (IWHOD) Athens, Greece, March 2019.

6. G. Patten, M.-A. Davies, G. Maartens, M. von Lettow, M. Fox, N. Sipambo, R. Wood, K. Technau, B. Eley, H. Prozesky, M. Osler, G. Fatti, F. Tanser, C. Chimbetete, K. Malisita, J. Muhairwe, J. Burgos-Soto, C. Kunzekwenyika, S. Phiri, N. Anderegg, N. Ford on behalf of IeDEA Southern Africa. Characteristics and outcomes of adults and children >5 years with advanced HIV disease in Southern Africa. 23rd International Workshop on HIV and Hepatitis Observational Databases (IWHOD) Athens, Greece, March 2019.

7. Geoffrey Fatti; Ashraf Grimwood; Sue-Ann Meehan, Jean B. Nachega, Jenna Nelson; Kelsea LaSorda; Gert van Zyl; Nelis Grobbelaar; Helen Ayles; Richard Hayes; Nulda Beyers; Sarah Fidler; Peter Bock on behalf of the HPTN 071 (PopART) study team. Better Virological Outcomes When Initiating Early ART In The HPTN 071 (PopART) Trial. Conference on Retroviruses and Opportunistic Infections (CROI), March 4 - 7, 2019, Seattle, Washington, USA. 

Research1
Pharmacy Assistants Programme

How could the youth bulge in sub-Saharan Africa be harnessed to overcome severe shortages in the health and social sector workforce? The WHO projects a global gap of 18 million health workers by 2030, primarily in low and middle-income countries, threatening to roll back gains in controlling the HIV epidemic. At the same time, many African countries are searching for solutions to a massive and growing employment crisis, as job creation is not keeping pace with the increasing population of youth entering the labor force. Adolescent girls and young women are disproportionately affected, while also facing higher risk for HIV than males of the same age. South Africa is a prime example of these trends, with broader relevance in Africa and other low and middle-income countries.

When asked about careers in health and social services, many youth think first of jobs as doctors or nurses that require years of higher education. Yet more accessible opportunities are emerging across the health and social sectors and associated value chains, in fields such as pharmacy, phlebotomy (drawing blood), and community health work. Many offer strong potential for advancement and professional development, especially for young women. Presenters will share learning about emerging jobs and career pathways for youth, while also taking a frank look at the systemic barriers that can exclude youth or limit advancement. We will discuss implications for youth employment programs, whether specifically focused on health and social services or more generally on skill development or employment. This webinar is based on research from USAID's Youth Power Action South Africa Health Workforce Assessment.

Kheth’Impilo had success with some of its programmes being rated among the top social innovations globally by the WHO/TDR and Oxford University in partnership with UCT and the Bertha Centre for Social Innovation.

Kheth’Impilo once again received international acclaim with the Pharmacy Assistant programme in regards to human resources for health which is prominently featured in the  South Africa Health Workforce Assessment (USAID, 2018).

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